Telomeres and Telomerase in Cancer: Overview and Therapeutic Potential
نویسندگان
چکیده
Telomeres are specialized structures of eukaryotic chromosomes that protect the tips chromosomes. prevent from losing base pair sequences at their ends, and also stop fusing together. Telomerase is an enzyme rebuilds telomeres maintains genomic stability by extending after each cell division. activity prevents cellular aging, known as senescence. Immortal lines can be created inducing expression telomerase in cells normally lack telomerase. Cells need to maintain integrity mutations lead cancer. Such activation mentioned above often cancer development preserving rapidly dividing cells. If a keeps overcomes limitations telomeres, cancerous tumor form. In healthy cells, achieve balance between limiting lifespan keeping growth bay.
 It has been established biomarker tumorigenesis. This makes attractive target for therapy, studies indicate methods treatment such oligonucleotides, immunotherapies, stabilization G-quadruplexes all hold immense possibilities field oncology. discoveries provide insight on potential play significant role prevention before tumorigenesis, or diagnosis. Therefore, viable therapeutic target, area interest study.
منابع مشابه
Telomeres and telomerase in cancer.
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Telomeres are the protective DNA-protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G-rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase. Telomerase is a specialized cellular ribonucleoprotein reverse transcriptase. By copying a short template sequence within ...
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ژورنال
عنوان ژورنال: Journal of Student Research
سال: 2022
ISSN: ['2167-1907']
DOI: https://doi.org/10.47611/jsrhs.v11i3.2718